Football League sides have voted to cut the number of substitutes from seven to five when the new season starts at their EGM at Leicester City's King Power Stadium.
A spokesman said: "This was felt to be a sensible and prudent step given the financial challenges facing many football clubs and the commitment made earlier this summer to adopt UEFA's Financial Fair Play framework."
The reduction in squad size will amongst other things reduce the cost of overnight stays ahead of away games, while a number of cash-strapped clubs have on occasion been unable to name a full 18-man party.
Clubs will still name seven subs in both the Carling Cup and FA Cup.
The Football League switched to using seven subs - from which managers can use three - in the summer of 2009.