Teddy Bishop and Cole Skuse return in place of Kevin Bru and Paul Anderson in an otherwise unchanged team as the Blues look for their fifth successive win at Sheffield Wednesday. New loan signing Jonny Williams is on the bench.
Skuse missed Saturday's 2-0 victory over Rotherham with a toe injury, while Bishop was rested.
Manager Mick McCarthy looks set to line his side up in the 4-3-3 formation utilised at Wigan last Monday and against the Millers.
Sheffield Wednesday: Westwood, Buxton, Loovens (c), Zayatte, Mattock, Maguire, Semedo, Palmer, Maghoma, Nuhiu, May. Subs: Kirkland, Dielna, Coke, Drenthe, Helan, Hope, Madine.
Town: Gerken, Parr, Mings, Berra, Chambers (c), Skuse, Hyam, Bishop, McGoldrick, Murphy, Sammon. Subs: Bialkowski, Smith, Anderson, Bajner, Bru, Tabb, Williams.