Myles Kenlock and Jordan Spence replace the injured Steven Taylor and Christophe Berra as Town boss Mick McCarthy names the side which played much of Saturday’s 1-0 win at Aston Villa.
Kenlock will play at left wing-back with Spence, Jonas Knudsen and skipper Luke Chambers the three-man backline, while Josh Emmanuel will be the right wing-back. Bartosz Bialkowski was in goal.
In midfield, Toumani Diagouraga and Emyr Huws will be joined by Grant Ward with Cole Skuse out with an achilles injury. Up front, Tom Lawrence will again be partnered by David McGoldrick.
Second-placed Brighton, who have ex-Town loanee David Stockdale in goal, are unchanged.
Brighton: Stockdale, Bruno (c), Duffy, Dunk, Pocognoli, Knockaert, Sidwell, Stephens, March, Baldock, Hemed. Walton, Tomori, Kayal, Skalak, Murphy, Akpom, Murray.
Town: Bialkowski, Spence, Chambers (c), Knudsen, Emmanuel, Diagouraga, Huws, Ward, Kenlock, Lawrence, McGoldrick. Subs: Gerken, Pitman, Digby, Bru, Sears, Douglas, Moore. Referee: Roger East (Wiltshire).