Freddie Sears and Teddy Bishop both start for Town as manager Paul Lambert makes four changes for the game at Blackpool.
Sears and Bishop, making their first league starts of the season, are either side of Will Keane in a front three as the Blues move to a 4-3-3 system.
Cole Skuse and Emyr Huws join Flynn Downes in midfield ahead of a back four of - from the right - Luke Woolfenden, skipper Luke Chambers, Josh Earl and Luke Garbutt.
"Gwion Edwards, Jon Nolan and Alan Judge drop to the bench having started last week’s 1-0 home defeat to Oxford, while Kayden Jackson serves the first game of his three-match ban.
Young striker Tyreece Simpson is on the bench for the first time in a league game, while Armando Dobra is also in the 18.
Blackpool name the same team for the third successive game with ex-Blues loanee Liam Feeney starting and ex-Town midfielder Grant Ward on the bench.
Blackpool: Maxwell, Turton, Moore, Husband, Macdonald, Feeney, Virtue, Ronan, Dewsbury-Hall, Delfouneso, Madine. Subs: Sims, Howe, Bola, Edwards, Spearing, Nuttall, Ward.
Town: Holy, Woolfenden, Chambers (c), Earl, Garbutt, Skuse, Downes, Huws, Sears, Bishop, Keane. Subs: Norris, Wilson, Edwards, Nolan, Judge, Dobra, Simpson. Referee: Christopher Sarginson (Staffordshire).