Christian Walton, Toto Nsiala, Lee Evans and Kyle Edwards return to the Blues side as they take on manager Paul Cook’s former club Portsmouth at Fratton Park.
Walton takes over in goal with Vaclav Hladky dropping to the bench alongside Cameron Burgess, who is replaced at the centre of the defence by Nsiala.
Evans comes back into midfield having missed Saturday’s 2-2 draw at Cambridge as his wife was having a baby with Idris El Mizouni among the subs. Edwards is on the left wing with Scott Fraser absent from the 18.
Former Pompey man Conor Chaplin continues in the number 10 role and Sone Aluko is again on the right having scored twice at the Abbey Stadium with Bersant Celina and Wes Burns again on the bench.
On-loan Aston Villa forward Louie Barry returns to the 18 but with no place for Kayden Jackson, who was in the squad at the weekend, or James Norwood.
For Portsmouth, Ronan Curtis returns to their line-up after suspension, while ex-Blues loanee Ryan Tunnicliffe also starts. Winger Michael Jacobs, who came close to joining Town over the summer, is on the bench.
Portsmouth: Bazunu, Freeman, Raggett, Williams, Romeo, Tunnicliffe, Morrell, Brown (c), Harness, Curtis, Marquis. Subs: Bass, Ogilvie, Thompson, Azeez, Hackett, Hirst, Jacobs.
Town: Walton, Donacien, Edmundson, Nsiala, Penney, Morsy (c), Evans, Aluko, Chaplin, Edwards, Bonne. Subs: Hladky, Burgess, Harper, El Mizouni, Burns, Celina, Barry. Referee: Josh Smith (Bedfordshire).