George Edmundson, Kane Vincent-Young, Lee Evans, Sone Aluko and Kyle Edwards return to the Town side as interim manager John McGreal takes charge of the Blues for the first time at Charlton.
Edmundson, who missed out at the weekend with an achilles problem, joins Toto Nsiala at centre-half with Vincent-Young at left-back, a role he played under McGreal at Colchester United. Janoi Donacien continues at right-back with Christian Walton in goal.
In midfield, Evans joins skipper Sam Morsy in the centre of midfield with Aluko on the right and Edwards on the left with Scott Fraser looking set to be the number 10 behind former Charlton striker Macauley Bonne.
From the side which drew 0-0 with Barrow on Saturday, Conor Chaplin, Idris El Mizouni and Cameron Burgess are on the bench, while Bailey Clements and Kayden Jackson are left out of the 18.
Bersant Celina is again absent having suffered a knock in training at the end of last week, while young midfielder Cameron Humphreys is again on the bench having impressed as a sub on Saturday.
For Charlton, skipper Jason Pearce returns to their back three after a knee problem, while keeper Craig MacGillivray also comes into the side.
Charlton: MacGillivray; Clare, Pearce (c), Famewo; Jaiyesimi, Gilbey, Dobson, Lee, Purrington; Stockley, Washington. Subs: Henderson, Elerewe, Souaré, Watson, Kirk, Leko, Davison.
Town: Walton, Vincent-Young, Nsiala, Edmundson, Donacien, Evans, Morsy (c), Aluko, Fraser, Edwards, Bonne. Subs: Hladky, Burgess, Penney, El Mizouni, Humphreys, Chaplin, Pigott. Referee: Christopher Sarginson (Staffordshire).