Goals from Wes Burns and Kayden Jackson have given the Blues a 2-0 half-time lead over Lincoln City.
Sone Aluko and Tyreeq Bakinson returned to the Town XI with the on-loan Bristol City man joining skipper Sam Morsy in central midfield.
Bersant Celina moved further forward as one of two number 10s along with Aluko with Jackson the central striker. Joe Pigott and Conor Chaplin dropped to the bench.
Lincoln made three changes from the team which beat Sheffield Wednesday 3-1 on Saturday with keeper Jordan Wright making his first start and Adam Jackson and Liam Cullen coming into the line-up for Joe Walsh and Tom Hopper, who were among the subs, and the injured Josh Griffiths.
Former Blues midfielder Teddy Bishop was among the Imps' subs, who included no goalkeeper.
Prior to kick-off there was a minute’s applause as the two clubs, Town wearing all blue and the Imps their all yellow third kit, showed their solidarity with the people of Ukraine.
The Blues almost scored in the second minute when, after a slick move which began on the left, Burns fed Janoi Donacien on the right and the defender cut back to the Welshman, who shot over.
Town, with around 25,000 fans backing them, continued the early intensity with Aluko winning the ball following the goal-kick and Burns sending in a low ball which was too far in front of his team-mates.
On 10 Aluko brilliantly took a ball between two defenders and sent Burns away on the right but the wing-back was let down by the pitch and the ball went out of play.
Six minutes later, with Town having continued to dominate, Jackson claimed a penalty when he chased Celina’s chipped ball behind the visitors’ defence and TJ Eyoma took it away from him. Referee Tom Reeves showed no interest in the Town striker’s appeals.
In the 20th minute Luke Woolfenden exchanged passes with Aluko midway inside the Lincoln half and eventually received the ball again inside the area on the byline from Burns but the centre-half’s cutback was diverted away from goal. Aluko got onto the loose ball but his curling shot from the edge of the area was also blocked.
The Blues had been on top since the start and in the 22nd minute they got the goal their performance deserved.
Morsy brought the ball out from the back and found Celina, who bundled past a man in the centre circle and played the ball into the path of Jackson, who burst down the left and played it across the area. Morsy, who had made his way forward, left it for Burns, who slammed in his 11th goal of the season.
Having established their lead, Town went looking for a second and on the half hour, Donacien found himself on the byline on the right with the ball and about to cut it across following a mix-up between two Lincoln defenders. However, referee Reeves stopped play for an earlier Imps infringement, much to the frustration of Donacien and his team-mates.
But the Blues and their already noisy fans only had to wait another two minutes for the second goal.
Burns left Morgan Whittaker in a heap down the right then cut back to Morsy, who played it to the far post to Jackson, who tapped home.
Lincoln argued that the striker had been offside - and it looked very tight - as he turned home his third goal in five games but neither referee Reeves or his assistant were interested.
Town set about getting a third. Celina brought the ball forward before seeing a shot blocked, then Morsy did much the same before feeding Jackson to his right and the striker’s effort deflected behind.
From Aluko’s corner, the ball dropped loose and Morsy had two goes and Jackson one before Lincoln somehow got it away from danger.
On 39, Regan Poole was booked for a foul on Aluko as Lincoln began to become frustrated with the evening’s proceedings.
In injury time, skipper Conor McGrandles joined him for a late tackle on Celina, which led to a confrontation between the pair, Aluko pulling McGrandles away from the situation before matters escalated. McGrandles and Celina, who had appeared to do little wrong, were both booked.
Just before the whistle, Chris Maguire was also shown a yellow card for a foul on Aluko, whose twinkle-toed skills had taken him out of a tight area into space. Celina hit the wall with his 30-yard free-kick.
The Town players were warmly applauded off having dominated from start to finish and well worthy of their two-goal lead, which might well have been even more.
Town: Walton, Donacien, Woolfenden, Edmundson, Burns, Morsy (c), Bakinson, Thompson, Aluko, Celina, Jackson. Subs: Hladky, Burgess, Carroll, Chaplin, Bonne, Pigott, Norwood.
Lincoln: Wright, Poole, Eyoma, Jackson, Whittaker, Norton-Cuffy, McGrandles (c), Fiorini, Marquis, Maguire, Cullen.Subs: Sanders, Sorensen, Bramall, Hopper, Walsh, Scully, Bishop. Referee: Tom Reeves (Birmingham).