| New update on the Pfizer vaccine 16:15 - Nov 18 with 2599 views | StokieBlue |
So after analysing more of their data Pfizer have said the vaccine has 95% efficacy and has been passed as safe. They have detailed the % of patients who had side-effects:
"It said the updated analysis was based on 8,000 trial participants. Pfizer said in a previous analysis that 3.7% of 6,000 volunteers had experienced fatigue.
Pfizer also added that there was a second adverse event with a frequency of at least 2% in the trial. The US drugmaker said 2% of participants experienced headaches after the second shot."
So a 4% chance of wanting a sleep and a 2% chance of a headache. I don't think many will be unhappy with those odds or side-effects.
SB |  | | |  |
| New update on the Pfizer vaccine on 16:21 - Nov 18 with 2205 views | J2BLUE |
Agree. That's why people posting stuff about lots of side effects with no evidence need to be taken with a pinch of salt.
Really hoping for positive news of the Oxford trial. Fingers crossed. |  |
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| New update on the Pfizer vaccine on 16:23 - Nov 18 with 2186 views | bluelagos |
BBC reported earlier that they also said it had 94% effectiveness in the over 65s which has to be excellent news. Also effective across all ethnic groups too. |  |
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| New update on the Pfizer vaccine on 16:23 - Nov 18 with 2196 views | BlueBadger |
You'll be laughing on the other side of your face when a rampaging ocelot kills your wife's cousin's dog groomer's auntie's hairdresser the day after you get your jab. [Post edited 18 Nov 2020 16:31]
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| New update on the Pfizer vaccine on 16:25 - Nov 18 with 2169 views | Fixed_It |
On that basis, my missus must have already had the vaccine!   |  |
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| New update on the Pfizer vaccine on 16:25 - Nov 18 with 2155 views | Rocky |
| New update on the Pfizer vaccine on 16:23 - Nov 18 by BlueBadger |
You'll be laughing on the other side of your face when a rampaging ocelot kills your wife's cousin's dog groomer's auntie's hairdresser the day after you get your jab. [Post edited 18 Nov 2020 16:31]
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Is that one of the side effects? |  | | |
| New update on the Pfizer vaccine on 16:26 - Nov 18 with 2142 views | hype313 |
Gutted, I was hoping to grow a tail. |  |
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| New update on the Pfizer vaccine on 16:28 - Nov 18 with 2133 views | bluelagos |
| New update on the Pfizer vaccine on 16:25 - Nov 18 by Fixed_It |
On that basis, my missus must have already had the vaccine! |
Made me laugh. Which is not good seeing as how I came off the bike earlier and my ribs are aching like fck.
*Be careful out there guys - the roads are covered in sh1te, especially bends that don't get any sun so the mud/leaves stay wet :-( | |
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| New update on the Pfizer vaccine on 16:31 - Nov 18 with 2132 views | homer_123 |
It's quite astonishing that it has a 94%/95% efficacy.
Given we know that the flu is different, your average flu vaccine has around 40% to 60% efficacy.
So it's quite remarkable to see this new vaccine at this level and with limited side effects that are significantly less sever than Covid (i.e. the negative side effects are still significantly better than contracting Covid).
This vaccine still has major hurdles to overcome both in terms of delivery, storage and then roll out. But - it's looking better and better. |  |
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| New update on the Pfizer vaccine on 18:01 - Nov 18 with 2018 views | Illinoisblue |
| New update on the Pfizer vaccine on 16:31 - Nov 18 by homer_123 |
It's quite astonishing that it has a 94%/95% efficacy.
Given we know that the flu is different, your average flu vaccine has around 40% to 60% efficacy.
So it's quite remarkable to see this new vaccine at this level and with limited side effects that are significantly less sever than Covid (i.e. the negative side effects are still significantly better than contracting Covid).
This vaccine still has major hurdles to overcome both in terms of delivery, storage and then roll out. But - it's looking better and better. |
The logistics could be the problem, doesn’t the vaccine have to be stored at minus 80 temps or something ? |  |
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| New update on the Pfizer vaccine on 18:04 - Nov 18 with 2012 views | SpruceMoose |
Seeing as I have had a 100% chance of waking up tired with a headache every day thanks to a Herculean drinking effort throughout lockdown, I like those odds. |  |
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"Imagine being a heterosexual white male in Britain at this moment. How bad is that. Everything you say is racist, everything you say is homophobic. The Woke community have really f****d this country." | | Poll: | Selectamod |
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| New update on the Pfizer vaccine on 18:17 - Nov 18 with 1963 views | gordon |
| New update on the Pfizer vaccine on 16:31 - Nov 18 by homer_123 |
It's quite astonishing that it has a 94%/95% efficacy.
Given we know that the flu is different, your average flu vaccine has around 40% to 60% efficacy.
So it's quite remarkable to see this new vaccine at this level and with limited side effects that are significantly less sever than Covid (i.e. the negative side effects are still significantly better than contracting Covid).
This vaccine still has major hurdles to overcome both in terms of delivery, storage and then roll out. But - it's looking better and better. |
Presume it's genetically more stable than infuenza viruses but haven't really seen much about that recently, may also be just because of the relatively brief period it's been circulating in humans that make these vaccines pretty effective. |  | | |
| New update on the Pfizer vaccine on 18:19 - Nov 18 with 1956 views | Trequartista |
I'm curious as to how that has risen to 95% from 90% last week. |  |
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| New update on the Pfizer vaccine on 18:21 - Nov 18 with 1946 views | jaykay |
| New update on the Pfizer vaccine on 16:21 - Nov 18 by J2BLUE |
Agree. That's why people posting stuff about lots of side effects with no evidence need to be taken with a pinch of salt.
Really hoping for positive news of the Oxford trial. Fingers crossed. |
you only have to look at any medicine , you will find a list of side effects and most of them are a long list. you don't see many people moaning and panicking about them. if things get back to normal through this vaccine , so my daughter and son can come to visit us 2 o.a.ps.
i will put up with headaches etc for a day or 2 |  |
| forensic experts say footers and spruces fingerprints were not found at the scene after the weekends rows |
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| New update on the Pfizer vaccine on 18:23 - Nov 18 with 1943 views | BlueBadger |
| New update on the Pfizer vaccine on 18:19 - Nov 18 by Trequartista |
I'm curious as to how that has risen to 95% from 90% last week. |
Further analysis of the data, like what Stokie says.
Early data tends to be relatively conservative, then things get number crunched a bit as the intricacies are worked through. | |
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| New update on the Pfizer vaccine on 18:25 - Nov 18 with 1933 views | Illinoisblue |
| New update on the Pfizer vaccine on 18:19 - Nov 18 by Trequartista |
I'm curious as to how that has risen to 95% from 90% last week. |
Gotta juice that share price! (And hey, if it gets us out of this mess they can make as much money as they want) | |
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| New update on the Pfizer vaccine on 18:42 - Nov 18 with 1902 views | Trequartista |
| New update on the Pfizer vaccine on 18:23 - Nov 18 by BlueBadger |
Further analysis of the data, like what Stokie says.
Early data tends to be relatively conservative, then things get number crunched a bit as the intricacies are worked through. |
As i understand it, there are thousands of volunteers, but the percentages are not worked out on how many of those vaccinated get covid, because there is no way of knowing if they have been exposed to it (you can't deliberately expose them), so it is a percentage of those who develop covid with the placebo against total covid cases.
This means these percentages are highly volatile because they are based on small numbers. Last week the results were based on 94 covid cases, so for 90% success there must have been 85 placebo covids and 9 vaccine covids.
CNN report the new data is based on 171 cases of covid of which 162 had the placebo and 9 had the vaccine making 95%.
Presuming the second set of data is an extension of the first set of data, the second set case size is almost double the case size of the first, yet there were no more vaccine covid cases in the second set.
That seems very volatile to me in that the percentage of such low numbers can swing from 90% to 100% giving 95% overall.
I wonder if the sample sizes were taken at the optimum time to show the Pfizer vaccine was 1% better than the Minerva vaccine.
Important to note though that these percentages are all much better than the 50%-60% hoped for and this all bodes well for the pending Oxford results of which doses UK has the most direct and plentiful access. | |
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| New update on the Pfizer vaccine on 18:46 - Nov 18 with 1880 views | BlueBadger |
| New update on the Pfizer vaccine on 16:23 - Nov 18 by BlueBadger |
You'll be laughing on the other side of your face when a rampaging ocelot kills your wife's cousin's dog groomer's auntie's hairdresser the day after you get your jab. [Post edited 18 Nov 2020 16:31]
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Wow, this one's attracted TWO Downvote Weirdos. | |
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| New update on the Pfizer vaccine on 18:49 - Nov 18 with 1870 views | NthQldITFC |
| New update on the Pfizer vaccine on 18:19 - Nov 18 by Trequartista |
I'm curious as to how that has risen to 95% from 90% last week. |
The cynics amongst us might think it was because the Moderna vaccine has been touted as 94.5% effective. Not me, I trust big pharma (for the moment!)
https://www.bbc.co.uk/news/health-54902908 |  |
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| New update on the Pfizer vaccine on 18:51 - Nov 18 with 1862 views | NthQldITFC |
| New update on the Pfizer vaccine on 16:25 - Nov 18 by Fixed_It |
On that basis, my missus must have already had the vaccine! |
Can't say I've noticed. | |
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| New update on the Pfizer vaccine on 18:56 - Nov 18 with 1838 views | Trequartista |
Yes i mentioned this in my previous reply. I don't think they're changing the results, but they may be choosing the point at which they produce an interim result.
Discovering if the vaccine prevents serious Covid if it doesn't prevent infection is almost just as important. Moderna reported 0 (0%), Pfizer reported 1 (11%) but the Pfizer placebo was 8/162 (5%), so the sample numbers are far too low to draw any conclusions. | |
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| New update on the Pfizer vaccine on 18:59 - Nov 18 with 1832 views | StokieBlue |
| New update on the Pfizer vaccine on 18:01 - Nov 18 by Illinoisblue |
The logistics could be the problem, doesn’t the vaccine have to be stored at minus 80 temps or something ? |
According to a podcast I listened to, it needs to be transported longer distances at -80C but then can keep in normal fridges for a few days.
That should be logistically possible even for our government.
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| New update on the Pfizer vaccine on 19:02 - Nov 18 with 1817 views | J2BLUE |
| New update on the Pfizer vaccine on 18:59 - Nov 18 by StokieBlue |
According to a podcast I listened to, it needs to be transported longer distances at -80C but then can keep in normal fridges for a few days.
That should be logistically possible even for our government.
SB |
That would be brilliant if that's true. | |
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| New update on the Pfizer vaccine on 19:07 - Nov 18 with 1803 views | StokieBlue |
| New update on the Pfizer vaccine on 18:17 - Nov 18 by gordon |
Presume it's genetically more stable than infuenza viruses but haven't really seen much about that recently, may also be just because of the relatively brief period it's been circulating in humans that make these vaccines pretty effective. |
It's an RNA virus like the flu which mutate quicker than DNA viruses but thus far it's not been mutating that quickly.
The two vaccines thus far are mRNA viruses which are very different from other types of vaccinations which have come previously. They use mRNA to simulate the signature of the spike protein which the body then learns and can produce antibodies against. So rather than having the whole virus (even an attenuated version) in the vaccine there is just a simulation of a small part of the virus.
I believe it's hoped that the spike protein won't mutate as much as other parts of the virus and thus it will maintain it's effectiveness. I believe similar projects are underway for a generic flu vaccine but I guess C19 has become a more pressing need and thus is the first one to use this.
Obviously as you imply, if there is a massive mutation of the spike protein which then manages to outcompete the other strains in the wild then there could be issues but that is the same with any virus.
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| New update on the Pfizer vaccine on 19:08 - Nov 18 with 1798 views | StokieBlue |
| New update on the Pfizer vaccine on 19:02 - Nov 18 by J2BLUE |
That would be brilliant if that's true. |
I'll see if I can confirm this.
SB | | | |
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